Does methadone work for toothache?

Methadone is a substance categorized as a synthetic opioid able to provide a pronounced analgesic effect. While it is different from morphine by its chemical structure, the product, nevertheless, has a similar action. In the postwar period, Soviet scientists, upon researching effects of the drug (which belongs to the group of narcotic analgesics), began to use it as a substitution for morphine. Additionally, methadone shows much higher effectiveness compared to morphine in case of oral administration. Does methadone work for toothache? Read on to find out.

Since the mid-60s of the 20th century, the drug has been used to treat “opiate” drug addicts. To reduce the appearance of physical addiction to Methadone, the dosage is selected in such a way that it decreases gradually, but without any relevant deterioration of the patient’s state. This kind of treatment is accompanied by delivering psychotherapeutic sessions with the simultaneous administration of supportive drugs.

Since the drug (although it is used to treat addiction) is a narcotic drug itself, the practice of using it provokes a lot of controversial opinions among narcologists all over the world. with both a medical aspect and an organizational aspect being disputed. The distribution and consumption control should be done very carefully for this drug. Otherwise, Methadone can be available to drug addicts and used uncontrollably. Synonyms for the drug’s name are Adanon, Heptadone, Amidon, Fenadon, Physeptone and Dolofin.

Pharmacological Background

This drug is an opioid agonist. Agonists are substances which, when effecting receptors, provoke some kind of reaction in response. And conversely, antagonists are substances which reduce or block the receptors’ response to natural body signals. For example, morphine’s antagonist is naloxone.

Does methadone work for toothache photoMorphine activates receptors, and its molecules connect with the opioid receptors. Acting as a competitor, naloxone replaces a receptor, leaving no possibility for morphine molecules to connect to it.

The substance, unlike many other drugs, has a prolonged action – up to 36 hours. At the same time, it does not provoke a pronounced euphoric reaction. Due to this characteristic, the withdrawal syndrome once the drug’s effect is over can be minimized. The anesthetic effect of the substance appears in half an hour – an hour after the administration and lasts for approximately 5 hours. Taken orally, the preparation is rapidly absorbed from the digestive tract. Its bioavailability is as high as 80 – 95%.

The drug features a rather long half-life period (more than 24 hours), so, when the methadone-based substitution therapy is conducted, the product can be taken only once a day. The biotransformation of this drug occurs in the liver, and it is removed with feces and urine.

The product is available both in the form of a solution for injections and tablets.

Indications for Use

The preparation is used for two major purposes:

  • as an analgesic;
  • in frames of the substitution maintenance therapy in people suffering from opioid addiction.

In particular, using methadone for toothache seems to be a good idea.


There are several aspects to take into account when considering the administration of Metadone. Avoid using the drug in the following situations:

  1. The patient suffers from the respiratory embarrassment.
  2. The patient has an allergy to Methadone.
  3. When the patient is Pethidine- or Codeine-addicted (both being weak opioids), there is no sense to prescribe Methadone as the severity of the addiction will only increase, which can lead to a life-threatening condition.
  4. Using the drug in pregnant women is still under debate in the professional medium. Most doctors consider pregnancy a contraindication to the use of Methadone for toothache.

Side Effects

Prior to giving a positive answer to the question ‘Does methadone work for tooth pain?’, it is important to take into account that using this substance can cause numerous side effects too. The most common negative body reactions include:

  • Does methadone work for tooth pain photoconstipation;
  • excessive sweating;
  • insomnia;
  • attention focusing problems;
  • impotency;
  • nausea;
  • drowsiness;
  • euphoria;
  • constriction of eye pupils, etc.

General Influence on the Human Body

Methadone has a comprehensive effect on the human body. As consequences can be detrimental in severe cases, the administration of the product should always be done with the patient-specific body reactions in mind. There is, nonetheless, a number of common trends reported in terms of Methadone’s influence on body systems in general. Here are some important points to remember:

  1. methadone for toothache photoIn therapeutic dosages, Methadone has a sedative and analgesic effect.
  2. The preparation influences the nervous and cardiovascular systems in the first place.
  3. Smooth muscles are affected too.
  4. The overdose deteriorates the blood circulation, suppresses the breathing function and leads to kidney failures and pulmonary edema.
  5. In case of a chronic use, elevated blood pressure, rapid heartbeat, bile ducts spasms, sluggishness and hyperglycemia (elevated blood glucose levels) can be expected.
  6. While Methadone-addict individuals can survive doses up to 200 mg, even the amount of about 50 mg can be fatal for a common unprepared patient.

The relevant facts given above can help you take an informed decision on whether it is worth trying Methadone as a tooth pain killer.

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