Panadol belongs to the group of non-selective non-steroidal anti-inflammatory drugs. Its active agent is paracetamol, which is known for its pronounced antipyretic and analgesic action. The mechanism of the drug’s action is primarily associated with the inhibition of the prostaglandins synthesis, which occurs due to a decrease in the activity of the cyclooxygenase enzyme. At the same time, the product shows only weak anti-inflammatory action because Paracetamol is deactivated by cell peroxydases. The product’s analgesic and antipyretic effect is delivered through reducing the number of prostaglandins in the central nervous system.
Panadol comes in tablets, which are to be stored in a dry dark place, out of the reach of children. Remember also that the product’s shelf life is 5 years maximum, so always pay attention to the expiry date. The storage temperature is 25 degrees Celsius maximum.
Indications for Use
Panadol is used to relieve mild or moderate pain of various genesis. The product can be used for:
Attacks of migraine or similar pains;
Myalgia-related pain syndrome;
Rheumatic pains and neuralgia;
Along with that, Panadol can be used to successfully relieve symptoms of influenza and acute respiratory viral infections. It is also known as an effective antifebrile remedy.
Panadol should be never prescribed to patients showing hypersensitivity to its core ingredient, paracetamol, in case of severe kidney and liver dysfunctions, hyperbilirubinemia, the deficit of glucose-6-phosphate dehydrogenase, insufficient hematogenesis as well as to patients suffering from chronic alcoholism. Also, it should not be administered to children under six years old as well as to pregnant and breastfeeding women.
Paracetamol, panadol’s active substance, has a pronounced embryotoxic, mutagenic and teratogenic effect and is able to penetrate through the hematoplacental barrier. Therefore, including the medication into the therapy of pregnant women should be avoided by all means and is possible only in case of emergency, when expected benefits for the mother are estimated as significantly superior to the risks for the future baby.
Panadol for toothache can be used by women at the stage of lactation, but only according to their doctor’s recommendations. The product should not be prescribed to elderly patients and patients who are prone to vasospasms. People with atherosclerosis and thrombosis constitute another group of risk. Insomnia, glaucoma, prostate hypertrophy, epilepsy, cardiac conduction disorder, decompensated cardiac deficiency and diabetes mellitus are also medical conditions that make using Panadol undesirable or even impossible.
Please, keep in mind that taking the drug reduces the effectiveness of diuretics and a whole number of other medicines as it reduces their absorption drastically.
Mode of Administration and Doses
Panadol extra for toothache is for oral use. It is recommended to swallow the full tablet and drink a sufficient amount of water afterwards. Never chew or grind the pills. Preferably, the duration of the course and the dosage applied should be determined by a medical specialist. The general guidelines to refer to are the following:
Adults and children above 12 can take 500 or 1000 mg of the drug 3-4 times a day.
Children between 6 and 12 years old can take 250 or 500 mg of Panadol 3 to 4 times a day.
The maximum allowed dosage is 4000 mg for adults and 2000 mg for children.
Taking the drug is prohibited to women during the period of pregnancy and lactation, as well as to children under the age of 12 years old.
Make sure the interval between the intakes is 4 hours minimum. It is recommended to never continue taking the medicine for more than seven days. The specific duration should be determined by a patient’s doctor on an individual basis. Along with that, the dosage is to be adjusted if the patient suffers from a liver dysfunction.
The overdose when taking Panadol Extra Strength for toothache can result in a toxic damage of the liver, dyspeptic disorders, skin pallor, lower appetite, deterioration of carbohydrate metabolism and metabolic acidosis. In very severe cases, encephalopathy, hypoglycemia, bleeding and even coma can occur. In some cases, with the overdose of the drug, the development of drowsiness, psychomotor agitation, arrhythmia, tremor of limbs and seizures were reported.
To eliminate the intoxication symptoms, the stomach lavage is usually performed. Additionally, the patient is administered enterosorbents and N-acetylcysteine along with some kind of a symptomatic therapy.
Taking Panadol Extra for tooth pain results in side effects only in very rare cases. When the drug is used by people showing the increased sensitivity, the patient may experience:
lower blood sugar levels,
and various allergic reactions.
The allergic reactions occasionally reported by patients include skin rash, itching, hives, Stevens-Johnson syndrome, Lyell syndrome, Quincke’s edema and even anaphylactic shock.